Research Results in Pharmacology (Dec 2015)

THE EFFECT OF HUMORAL FACTORS RELEASED BY HYPOPERFUSED PLACENTA ON FETAL DEVELOPMENT

  • Vladimir Gureev,
  • Oksana Antseferova,
  • Tatyana Lokteva,
  • Alexandr Dolzhikov

DOI
https://doi.org/10.18413/2500-235x-2015-1-4-39-44
Journal volume & issue
Vol. 1, no. 1
pp. 34 – 37

Abstract

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Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologies.

Keywords