Effects of Gancao Nourish-Yin Decoction on Liver Metabolic Profiles in hTNF-α Transgenic Arthritic Model Mice

Abstract

Objective Gancao Nourish-Yin Decoction (GNYD) has been applied to clinical rheumatoid arthritis (RA) patients, and it had shown effectiveness not only in disease activity controlling but also in improving patients' physical status. However, its mechanism of function has not been investigated. Metabolic perturbations have been associated with RA, and targeting the metabolic profile is one of the ways to manage the disease. The aim of this study is to observe the effect of GNYD on metabolic changes of human tumor necrosis factor α (hTNF-α) transgenic arthritic model mice.

Keywords

• rheumatoid arthritis
• Gancao Nourish-Yin Decoction
• hTNF-α
• liver metabolism
• metabolomics