mBio
(Jun 2021)
The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral
<i>UL4</i>
/
<i>UL5</i>
Transcripts
Ana Cristina Gonzalez-Perez,
Markus Stempel,
Emanuel Wyler,
Christian Urban,
Antonio Piras,
Thomas Hennig,
Sabina Ganskih,
Yuanjie Wei,
Albert Heim,
Markus Landthaler,
Andreas Pichlmair,
Lars Dölken,
Mathias Munschauer,
Florian Erhard,
Melanie M. Brinkmann
Affiliations
Ana Cristina Gonzalez-Perez
ORCiD Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
Markus Stempel
ORCiD Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
Emanuel Wyler
Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
Christian Urban
School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany
Antonio Piras
School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany
Thomas Hennig
ORCiD Institute for Virology and Immunobiology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
Sabina Ganskih
Helmholtz-Institute for RNA-based Infection Research, HIRI, Würzburg, Germany
Yuanjie Wei
Helmholtz-Institute for RNA-based Infection Research, HIRI, Würzburg, Germany
Albert Heim
ORCiD Institute of Virology, Hannover Medical School, Hannover, Germany
Markus Landthaler
Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
Andreas Pichlmair
School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany
Lars Dölken
Institute for Virology and Immunobiology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
Mathias Munschauer
Helmholtz-Institute for RNA-based Infection Research, HIRI, Würzburg, Germany
Florian Erhard
Institute for Virology and Immunobiology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany
Melanie M. Brinkmann
ORCiD Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
DOI
https://doi.org/10.1128/mBio.02683-20
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.
WeChat QR code
Close
