WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Seong-Su Han; Kuo-Kuang Wen; María L. García-Rubio; Marc S. Wold; Andrés Aguilera; Wojciech Niedzwiedz; Yatin M. Vyas

doi:10.1038/s41467-022-31415-z

Nature Communications (Jun 2022)

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Seong-Su Han,
Kuo-Kuang Wen,
María L. García-Rubio,
Marc S. Wold,
Andrés Aguilera,
Wojciech Niedzwiedz,
Yatin M. Vyas

Affiliations

Seong-Su Han: Department of Pediatrics, PennState College of Medicine, PennState Health Children’s Hospital
Kuo-Kuang Wen: Department of Pediatrics, PennState College of Medicine, PennState Health Children’s Hospital
María L. García-Rubio: Andalusian Center of Molecular Biology and Regenerative Medicine CABIMER, Department of Genome Biology, University of Seville-CSIC-University Pablo de Olavide
Marc S. Wold: Department of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine
Andrés Aguilera: Andalusian Center of Molecular Biology and Regenerative Medicine CABIMER, Department of Genome Biology, University of Seville-CSIC-University Pablo de Olavide
Wojciech Niedzwiedz: The Institute of Cancer Research
Yatin M. Vyas: Department of Pediatrics, PennState College of Medicine, PennState Health Children’s Hospital

DOI: https://doi.org/10.1038/s41467-022-31415-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Cancer develops in Wiskott-Aldrich syndrome (WAS). Here the authors identify a role for WAS-protein (WASp) in the DNA stress-resolution pathway by promoting the function of Replication Protein A at replication forks after DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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