Communications Biology (Mar 2022)

Activated endothelial cells induce a distinct type of astrocytic reactivity

  • Xavier Taylor,
  • Pablo Cisternas,
  • Nur Jury,
  • Pablo Martinez,
  • Xiaoqing Huang,
  • Yanwen You,
  • Javier Redding-Ochoa,
  • Ruben Vidal,
  • Jie Zhang,
  • Juan Troncoso,
  • Cristian A. Lasagna-Reeves

DOI
https://doi.org/10.1038/s42003-022-03237-8
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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Injured endothelial cells are shown to induce an A1 phenotype in astrocytes, characterized by a genetic signature associated with extracellular matrix remodeling factors (e.g. decorin and vascular Aß deposits).