First Russian experience of treating dyslipidemia with siRNA drugs in patients after heart transplantation

Abstract

Patients after heart transplantation (HT) are at very high risk for cardiovascular disease. Protocols for the management of heart recipients include the initiation of lipid-lowering therapy (LLT), regardless of sex, age and origin of heart failure. Given drug interactions and the risk of post-transplant complications, the LLT possibilities are limited in the transplanted population. The paper presents first Russian experience of using siRNA LLT for the treatment of dyslipidemia in solid organ transplant recipients.

Keywords

• heart transplantation
• dyslipidaemia
• sirna
• inclisiran