Communications Biology (Feb 2021)

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition

  • Shinya Mimasu,
  • Hiroaki Yamagishi,
  • Satoshi Kubo,
  • Mie Kiyohara,
  • Toshihiro Matsuda,
  • Toshiko Yahata,
  • Heather A. Thomson,
  • Christopher D. Hupp,
  • Julie Liu,
  • Takao Okuda,
  • Kenichi Kakefuda

DOI
https://doi.org/10.1038/s42003-021-01666-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Mimasu et al. report a rat full-length structure of kynurenine 3-monooxygenase (KMO) in its membrane-embedded form, complexed with two inhibitors. They find that the dimeric interface of KMO is critical for its activity. This study provides insights into the drug development strategies that target KMO, an important regulator of tryptophan metabolism.