Iranian Journal of Colorectal Research (Dec 2016)

Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

  • Zahra Mojtahedi,
  • Somayeh Rezaeifard,
  • Zahra Faghih

Journal volume & issue
Vol. 4, no. 4

Abstract

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Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance inmicrobiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggestingthe contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.

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