Nature Communications (Apr 2020)
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells
- Jingjing Zhang,
- Manickam Gurusaran,
- Yasuhiro Fujiwara,
- Kexin Zhang,
- Meriem Echbarthi,
- Egor Vorontsov,
- Rui Guo,
- Devon F. Pendlebury,
- Intekhab Alam,
- Gabriel Livera,
- Martini Emmanuelle,
- P. Jeremy Wang,
- Jayakrishnan Nandakumar,
- Owen R. Davies,
- Hiroki Shibuya
Affiliations
- Jingjing Zhang
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Manickam Gurusaran
- Institute for Cell and Molecular Biosciences, Newcastle University
- Yasuhiro Fujiwara
- Institute for Quantitative Biosciences, University of Tokyo
- Kexin Zhang
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Meriem Echbarthi
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Egor Vorontsov
- Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg
- Rui Guo
- Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine
- Devon F. Pendlebury
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Intekhab Alam
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Gabriel Livera
- Laboratory of Development of the Gonads, UMRE008 Genetic Stability Stem Cells and Radiation, Université de Paris, Université Paris Saclay, CEA
- Martini Emmanuelle
- Laboratory of Development of the Gonads, UMRE008 Genetic Stability Stem Cells and Radiation, Université de Paris, Université Paris Saclay, CEA
- P. Jeremy Wang
- Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine
- Jayakrishnan Nandakumar
- Department of Molecular, Cellular, and Developmental Biology, University of Michigan
- Owen R. Davies
- Institute for Cell and Molecular Biosciences, Newcastle University
- Hiroki Shibuya
- Department of Chemistry and Molecular Biology, University of Gothenburg
- DOI
- https://doi.org/10.1038/s41467-020-15954-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.
