The diagnostic value of serum PSA, IL-6 and IL-10 levels in prostate cancer

Abstract

Objective To explore the diagnostic value of serum prostate-specific antigen （PSA）, interleukin-6 （IL-6） and interleukin-10 （IL-10） levels in prostate cancer by logistic regression and receiver operating characteristic （ROC） curve. Methods A total of 143 patients who first underwent prostate biospy in Department of Urology were selected and divided into the prostate cancer group （PCa） （n = 84） and non-prostate cancer group （non-PCa） （n = 59）. The differences in age, height, weight, body mass index （BMI）, complete blood cell count （CBC）, serum levels of total （tPSA） and free PSA （fPSA）, IL-6 and IL-10 were compared between two groups. Taking the pathological results as an dependent variable, and the multi-factor binary logistic regression equation was further incorporated to establish the final predictive model. The ROC curve was used to compare the predictive value of multiple indicators combined and single indicator in the new model for the diagnosis of prostate cancer. Results The mean age, absolute number of monocyte （M）, tPSA, IL-6 and IL-10 levels in the PCa group were significantly higher than those in the non-PCa group （all P < 0.05）, while the mean lymphoid/monocyte ratio （LMR） and f/tPSA were significantly lower than those in the non-PCa group （both P < 0.05）. Spearman rank correlation test showed that there was a significant positive correlation between IL-6 and IL-10 （rs = 0.602, P < 0.01）, and a weak correlation between age and tPSA （rs = 0.243, P = 0.003）. The results of logistic regression analysis demonstrated that age, tPSA and IL-6 were laboratory indicators that could independently diagnose malignant prostate tumors. A regression model was established： logit P = -7.811+0.098XAge+ 0.040XtPSA+0.092XIL-6. The area under the ROC curve （AUC） of the new diagnosis variable obtained by combined detection reached 0.832. When the cut-off value was 0.584, the sensitivity was 71.4% and the specificity was 84.7%, both higher than those of the individual indicator alone （both P < 0.05）. Conclusions IL-6 and IL-10 levels have certain clinical value in the diagnosis of prostate cancer. Age, tPSA and IL-6 are indicators which could independently predict and diagnose malignant prostate tumors. The combined detection of them could improve the diagnostic efficiency of prostate cancer.

Keywords

• |prostate cancer|interleukin|prostate-specific antigen|logistic regression|combined detection