A Novel Nonpeptide CGRP Receptor Antagonist, ‘Compound 1’ (WO98/11128) Is a High Affinity Competitive Antagonist at the CGRP1 Receptor in Human Coronary Arteries

• P. Hasbak,
• O. Saetrum Opgaard,
• K. Eskesen,
• S. Schifter,
• H. Arendrup,
• J. Longmore,
• L. Edvinsson

Affiliations

P. Hasbak

Department of Clinical Experimental Research, University Hospital of Copenhagen, Glostrup, Denmark

O. Saetrum Opgaard

Department of Pharmacology, College of Medicine, University of California at Irvine, Irvine, CA, USA

K. Eskesen

Department of Clinical Experimental Research, University Hospital of Copenhagen, Glostrup, Denmark

S. Schifter

Department of Clinical Physiology and Nuclear Medicine, University Hospital of Copenhagen, Glostrup, Denmark

H. Arendrup

Department of Thoracic Surgery, Rigshospitalet, Copenhagen, Denmark

J. Longmore

Merck Sharp & Dohme, Neuroscience Research Centre, Harlow, Essex, UK

L. Edvinsson

Department of Clinical Experimental Research, University Hospital of Copenhagen, Glostrup, Denmark