Nature Communications (Mar 2018)

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction

  • Verity A. Jackson,
  • Dimphna H. Meijer,
  • Maria Carrasquero,
  • Laura S. van Bezouwen,
  • Edward D. Lowe,
  • Colin Kleanthous,
  • Bert J. C. Janssen,
  • Elena Seiradake

DOI
https://doi.org/10.1038/s41467-018-03460-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Teneurins are cell-cell adhesion receptors that evolved through horizontal gene transfer in which a bacterial YD-repeat protein fused to a eukaryotic receptor. Here the authors present crystallographic and cryo-EM structures of two Teneurins, revealing an ancient YD-repeat protein super-fold.