Cells (2021-05-01)

From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas

  • Xueyuan Sun,
  • Sevin Turcan

DOI
https://doi.org/10.3390/cells10051225
Journal volume & issue
Vol. 10, no. 1225
p. 1225

Abstract

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In this review, we discuss the use of the alkylating agent temozolomide (TMZ) in the treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical (drug resistance and tumor recurrence) and preclinical settings (variabilities associated with in vitro models) in treating IDH-mutant glioma. Lastly, we summarize the emerging therapeutic targets that can potentially be used in combination with TMZ.

Keywords