Nature Communications (Oct 2020)
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
- Stephan Brouwer,
- Timothy C. Barnett,
- Diane Ly,
- Katherine J. Kasper,
- David M. P. De Oliveira,
- Tania Rivera-Hernandez,
- Amanda J. Cork,
- Liam McIntyre,
- Magnus G. Jespersen,
- Johanna Richter,
- Benjamin L. Schulz,
- Gordon Dougan,
- Victor Nizet,
- Kwok-Yung Yuen,
- Yuanhai You,
- John K. McCormick,
- Martina L. Sanderson-Smith,
- Mark R. Davies,
- Mark J. Walker
Affiliations
- Stephan Brouwer
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Timothy C. Barnett
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Diane Ly
- Illawarra Health and Medical Research Institute
- Katherine J. Kasper
- Department of Microbiology and Immunology and the Centre for Human Immunology, Schulich School of Medicine & Dentistry, Western University
- David M. P. De Oliveira
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Tania Rivera-Hernandez
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Amanda J. Cork
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Liam McIntyre
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Magnus G. Jespersen
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Johanna Richter
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Benjamin L. Schulz
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Gordon Dougan
- The Wellcome Trust Sanger Institute
- Victor Nizet
- Department of Pediatrics, University of California San Diego
- Kwok-Yung Yuen
- State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region
- Yuanhai You
- State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention
- John K. McCormick
- Department of Microbiology and Immunology and the Centre for Human Immunology, Schulich School of Medicine & Dentistry, Western University
- Martina L. Sanderson-Smith
- Illawarra Health and Medical Research Institute
- Mark R. Davies
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Mark J. Walker
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-020-18700-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.
