Polymers (May 2020)

Oxygen-Releasing Antibacterial Nanofibrous Scaffolds for Tissue Engineering Applications

  • Turdimuhammad Abdullah,
  • Kalamegam Gauthaman,
  • Ahmed H. Hammad,
  • Kasturi Joshi Navare,
  • Ahmed A. Alshahrie,
  • Sidi A. Bencherif,
  • Ali Tamayol,
  • Adnan Memic

DOI
https://doi.org/10.3390/polym12061233
Journal volume & issue
Vol. 12, no. 6
p. 1233

Abstract

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Lack of suitable auto/allografts has been delaying surgical interventions for the treatment of numerous disorders and has also caused a serious threat to public health. Tissue engineering could be one of the best alternatives to solve this issue. However, deficiency of oxygen supply in the wounded and implanted engineered tissues, caused by circulatory problems and insufficient angiogenesis, has been a rate-limiting step in translation of tissue-engineered grafts. To address this issue, we designed oxygen-releasing electrospun composite scaffolds, based on a previously developed hybrid polymeric matrix composed of poly(glycerol sebacate) (PGS) and poly(ε-caprolactone) (PCL). By performing ball-milling, we were able to embed a large percent of calcium peroxide (CP) nanoparticles into the PGS/PCL nanofibers able to generate oxygen. The composite scaffold exhibited a smooth fiber structure, while providing sustainable oxygen release for several days to a week, and significantly improved cell metabolic activity due to alleviation of hypoxic environment around primary bone-marrow-derived mesenchymal stem cells (BM-MSCs). Moreover, the composite scaffolds also showed good antibacterial performance. In conjunction to other improved features, such as degradation behavior, the developed scaffolds are promising biomaterials for various tissue-engineering and wound-healing applications.

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