Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Ashish Misra; Zhonghui Feng; Rachana R. Chandran; Inamul Kabir; Noemi Rotllan; Binod Aryal; Abdul Q. Sheikh; Ling Ding; Lingfeng Qin; Carlos Fernández-Hernando; George Tellides; Daniel M. Greif

doi:10.1038/s41467-018-04447-7

Nature Communications (May 2018)

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Ashish Misra,
Zhonghui Feng,
Rachana R. Chandran,
Inamul Kabir,
Noemi Rotllan,
Binod Aryal,
Abdul Q. Sheikh,
Ling Ding,
Lingfeng Qin,
Carlos Fernández-Hernando,
George Tellides,
Daniel M. Greif

Affiliations

Ashish Misra: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Zhonghui Feng: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Rachana R. Chandran: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Inamul Kabir: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Noemi Rotllan: Department of Comparative Medicine, Yale University School of Medicine
Binod Aryal: Department of Comparative Medicine, Yale University School of Medicine
Abdul Q. Sheikh: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Ling Ding: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine
Lingfeng Qin: Department of Surgery, Yale University School of Medicine
Carlos Fernández-Hernando: Department of Comparative Medicine, Yale University School of Medicine
George Tellides: Department of Surgery, Yale University School of Medicine
Daniel M. Greif: Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-04447-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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