Nature Communications (Oct 2020)
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation
- Yuhki Koike,
- Bo Li,
- Niloofar Ganji,
- Haitao Zhu,
- Hiromu Miyake,
- Yong Chen,
- Carol Lee,
- Maarten Janssen Lok,
- Carlos Zozaya,
- Ethan Lau,
- Dorothy Lee,
- Sinobol Chusilp,
- Zhen Zhang,
- Masaya Yamoto,
- Richard Y. Wu,
- Mikihiro Inoue,
- Keiichi Uchida,
- Masato Kusunoki,
- Paul Delgado-Olguin,
- Luc Mertens,
- Alan Daneman,
- Simon Eaton,
- Philip M. Sherman,
- Agostino Pierro
Affiliations
- Yuhki Koike
- Translational Medicine Program, The Hospital for Sick Children
- Bo Li
- Translational Medicine Program, The Hospital for Sick Children
- Niloofar Ganji
- Translational Medicine Program, The Hospital for Sick Children
- Haitao Zhu
- Translational Medicine Program, The Hospital for Sick Children
- Hiromu Miyake
- Translational Medicine Program, The Hospital for Sick Children
- Yong Chen
- Translational Medicine Program, The Hospital for Sick Children
- Carol Lee
- Translational Medicine Program, The Hospital for Sick Children
- Maarten Janssen Lok
- Translational Medicine Program, The Hospital for Sick Children
- Carlos Zozaya
- Division of Neonatology, The Hospital for Sick Children
- Ethan Lau
- Translational Medicine Program, The Hospital for Sick Children
- Dorothy Lee
- Translational Medicine Program, The Hospital for Sick Children
- Sinobol Chusilp
- Translational Medicine Program, The Hospital for Sick Children
- Zhen Zhang
- Translational Medicine Program, The Hospital for Sick Children
- Masaya Yamoto
- Translational Medicine Program, The Hospital for Sick Children
- Richard Y. Wu
- Cell Biology Program, Research Institute, Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children
- Mikihiro Inoue
- Departments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine
- Keiichi Uchida
- Departments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine
- Masato Kusunoki
- Departments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine
- Paul Delgado-Olguin
- Translational Medicine Program, The Hospital for Sick Children
- Luc Mertens
- The Labatt Family Heart Center, Cardiology, The Hospital for Sick Children, University of Toronto
- Alan Daneman
- Department of Diagnostic Imaging, Division of Nuclear Medicine, The Hospital for Sick Children, University of Toronto
- Simon Eaton
- UCL Great Ormond Street Institute of Child Health
- Philip M. Sherman
- Cell Biology Program, Research Institute, Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children
- Agostino Pierro
- Translational Medicine Program, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-020-18750-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Necrotizing enterocolitis (NEC) is one of the most lethal gastrointestinal emergencies in neonates needing precision treatment. Here the authors show that remote ischemic conditioning is a non-invasive therapeutic method that enhances blood flow in the intestine, reduces damage, and improves NEC outcome.
