SPINDOC binds PARP1 to facilitate PARylation

Fen Yang; Jianji Chen; Bin Liu; Guozhen Gao; Manu Sebastian; Collene Jeter; Jianjun Shen; Maria D. Person; Mark T. Bedford

doi:10.1038/s41467-021-26588-y

Nature Communications (Nov 2021)

SPINDOC binds PARP1 to facilitate PARylation

Fen Yang,
Jianji Chen,
Bin Liu,
Guozhen Gao,
Manu Sebastian,
Collene Jeter,
Jianjun Shen,
Maria D. Person,
Mark T. Bedford

Affiliations

Fen Yang: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Jianji Chen: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Bin Liu: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Guozhen Gao: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Manu Sebastian: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Collene Jeter: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Jianjun Shen: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
Maria D. Person: Center for Biomedical Research Support The University of Texas at Austin
Mark T. Bedford: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-021-26588-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1. Their results suggest a role for SPINDOC in the regulation of PARP1- mediated PARylation and the DNA damage response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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