Nature Communications (Jan 2023)
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
- Yuka Inaba,
- Emi Hashiuchi,
- Hitoshi Watanabe,
- Kumi Kimura,
- Yu Oshima,
- Kohsuke Tsuchiya,
- Shin Murai,
- Chiaki Takahashi,
- Michihiro Matsumoto,
- Shigetaka Kitajima,
- Yasuhiko Yamamoto,
- Masao Honda,
- Shun-ichiro Asahara,
- Kim Ravnskjaer,
- Shin-ichi Horike,
- Shuichi Kaneko,
- Masato Kasuga,
- Hiroyasu Nakano,
- Kenichi Harada,
- Hiroshi Inoue
Affiliations
- Yuka Inaba
- Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University
- Emi Hashiuchi
- Department of Physiology and Metabolism, Graduate School of Medical Sciences, Kanazawa University
- Hitoshi Watanabe
- Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University
- Kumi Kimura
- Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University
- Yu Oshima
- Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University
- Kohsuke Tsuchiya
- Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Shin Murai
- Department of Biochemistry, Toho University School of Medicine
- Chiaki Takahashi
- Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Michihiro Matsumoto
- Department of Molecular Metabolic Regulation, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
- Shigetaka Kitajima
- Medical Research Institute, Tokyo Medical and Dental University
- Yasuhiko Yamamoto
- Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University
- Masao Honda
- Department of Gastroenterology, Graduate School of Medicine, Kanazawa University
- Shun-ichiro Asahara
- Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine
- Kim Ravnskjaer
- Department of Biochemistry and Molecular Biology, University of Southern Denmark
- Shin-ichi Horike
- Research Center for Experimental Modeling of Human Disease, Kanazawa University
- Shuichi Kaneko
- Department of Gastroenterology, Graduate School of Medicine, Kanazawa University
- Masato Kasuga
- The Institute of Medical Science, Asahi Life Foundation
- Hiroyasu Nakano
- Department of Biochemistry, Toho University School of Medicine
- Kenichi Harada
- Departments of Human Pathology, Graduate School of Medical Sciences, Kanazawa University
- Hiroshi Inoue
- Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University
- DOI
- https://doi.org/10.1038/s41467-023-35804-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a regulator of necroptosis.
