Leukemia Research Reports (Jan 2022)
Acute promyelocytic leukemia in a long-standing HIV-positive patient: Case report and literature review
- Daniela P. Mendes-de-Almeida,
- Teresa de Souza Fernandez,
- Viviane Lamim Lovatel,
- Moises Martins da Rocha,
- Bernadete Evangelho Gomes,
- Bárbara C.R. Monte-Mór,
- Danielle Tavares Vianna,
- Marília T.G. Alcoforado,
- João Marcello P.B. Kronemberg,
- João Pedro S.C. Cardoso,
- Vanessa da Gama Oliveira,
- Joanna Bokel,
- Alexandre G. Vizzoni,
- Estevão Portela Nunes,
- Beatriz Grinsztejn
Affiliations
- Daniela P. Mendes-de-Almeida
- Hematology Department, Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil; Research Center, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil; Corresponding author at: Department of Hematology, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
- Teresa de Souza Fernandez
- Cytogenetic Department, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
- Viviane Lamim Lovatel
- Cytogenetic Department, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
- Moises Martins da Rocha
- Cytogenetic Department, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
- Bernadete Evangelho Gomes
- Immunology Laboratory, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
- Bárbara C.R. Monte-Mór
- Molecular Biology Laboratory, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil
- Danielle Tavares Vianna
- Molecular Biology Laboratory, Bone Marrow Transplantation Center (CEMO), National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil; Department of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
- Marília T.G. Alcoforado
- Intensive Care Unit, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil
- João Marcello P.B. Kronemberg
- Intensive Care Unit, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil
- João Pedro S.C. Cardoso
- Intensive Care Unit, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil
- Vanessa da Gama Oliveira
- Department of Pharmacy, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil
- Joanna Bokel
- Hematology Department, Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil; Onco-Hematology Unit, Clínica São Vicente, Rio de Janeiro, Brazil
- Alexandre G. Vizzoni
- Hematology Department, Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
- Estevão Portela Nunes
- Laboratory of Clinical Research on STD/AIDS, Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
- Beatriz Grinsztejn
- Laboratory of Clinical Research on STD/AIDS, Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
- Journal volume & issue
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Vol. 18
p. 100339
Abstract
The use of antiretroviral therapy has drastically improved the life quality and prognosis of people living with the human immunodeficiency virus (HIV). The risk of acute myeloid leukemia (AML) currently does not appear to be significantly increased compared to the general population. Acute promyelocytic leukemia (APL), infrequent in people with HIV, is a distinct subtype of AML with unique molecular pathogenesis, clinical manifestations, and treatment. Herein we describe a fatal case of APL hypogranular variant in an HIV-positive patient presenting with hyperleukocytosis. Also, we conducted a literature review of the ten cases reported so far.
