Effects of Gamma Radiation-Induced Crosslinking of Collagen Type I Coated Dental Titanium Implants on Osseointegration and Bone Regeneration
Won-Tak Cho,
So-Yeun Kim,
Sung-In Jung,
Seong-Soo Kang,
Se-Eun Kim,
Su-Hyun Hwang,
Chang-Mo Jeong,
Jung-Bo Huh
Affiliations
Won-Tak Cho
Department of Prosthodontics, Dental Research Institute, Dental and Life Sciences Institute, Education and Research Team for Life Science on Dentistry, School of Dentistry, Pusan National University, Yangsan-si 50612, Korea
So-Yeun Kim
Department of Prosthodontics, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
Sung-In Jung
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 29 Geumgu-gil, Jeongeup-si 56212, Korea
Seong-Soo Kang
Department of Veterinary Surgery and R&BD Center, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
Se-Eun Kim
Department of Veterinary Surgery and R&BD Center, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
Su-Hyun Hwang
Department of Prosthodontics, Dental Research Institute, Dental and Life Sciences Institute, Education and Research Team for Life Science on Dentistry, School of Dentistry, Pusan National University, Yangsan-si 50612, Korea
Chang-Mo Jeong
Department of Prosthodontics, Dental Research Institute, Dental and Life Sciences Institute, Education and Research Team for Life Science on Dentistry, School of Dentistry, Pusan National University, Yangsan-si 50612, Korea
Jung-Bo Huh
Department of Prosthodontics, Dental Research Institute, Dental and Life Sciences Institute, Education and Research Team for Life Science on Dentistry, School of Dentistry, Pusan National University, Yangsan-si 50612, Korea
This study aimed to compare two methods of crosslinking collagen type I on implanted titanium surfaces, that is, using glutaraldehyde (GA) or gamma-rays (GRs), in a beagle dog model. For in vivo experiments, implants were allocated to three groups and applied to mandibular bone defects in beagle dogs; Group SLA; non-treated Sandblasted, large grit, acid-etched (SLA) implants, Group GA; SLA implants coated with GA crosslinked collagen type I, Group GR; SLA surface implants coated with collagen type I and crosslinked using 25 kGy of 60Co gamma radiation. New bone μCT volumes were obtained, and histologic and histometric analyses were performed in regions of interest. The GR group had significantly better new bone areas (NBAs) and bone to implant contact (BIC) results than the SLA group (p p > 0.05). Within the limits of this study, gamma-ray collagen crosslinking on titanium implants can be considered a substitute for glutaraldehyde crosslinking.