Nature Communications (May 2019)

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

  • Korneliusz Golebski,
  • Xavier R. Ros,
  • Maho Nagasawa,
  • Sophie van Tol,
  • Balthasar A. Heesters,
  • Hajar Aglmous,
  • Chantal M. A. Kradolfer,
  • Medya M. Shikhagaie,
  • Sven Seys,
  • P. W. Hellings,
  • Cornelis M. van Drunen,
  • Wytske J. Fokkens,
  • Hergen Spits,
  • Suzanne M. Bal

DOI
https://doi.org/10.1038/s41467-019-09883-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.