Elevated serum levels of 8-hydroxy-2-deoxyguanosine in mild-moderate acne vulgaris

Abstract

Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous unit. Although some mechanisms have been suggested in the etiopathogenesis of AV in several studies, they have not yet been clarified. This study aims to investigate the level of 8-hydroxy-2’-deoxyguanosine (8-OHdG) in acne vulgaris and its relationship with disease severity. Thirty-five patients with mild to moderate acne vulgaris and 30 healthy control participants were included in the study. The clinical severity of AV was determined by using the global acne score (GAS). The 8-OHdG level was measured by an enzyme-linked immunosorbent assay (ELISA). Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) scores were measured as oxidative stress markers. Levels of 8-OHdG were higher in AV compared to healthy controls (P = 0.036). A strong positive correlation between GAS and 8-OHdG was found in those with AV (p = 0.007, r = 0.444). And while TAS and TOS levels were significantly lower in AV patients, OSI levels were found to be significantly higher compared to healthy controls (p [Med-Science 2018; 7(2.000): 319-21]

Keywords

• Acne vulgaris
• oxidative stress
• 8-Hydroxy-2’-Deoxyguanosine