Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Konstantin Stoletov; Lian Willetts; Robert J. Paproski; David J. Bond; Srijan Raha; Juan Jovel; Benjamin Adam; Amy E. Robertson; Francis Wong; Emma Woolner; Deborah L. Sosnowski; Tarek A. Bismar; Gane Ka-Shu Wong; Andries Zijlstra; John D. Lewis

doi:10.1038/s41467-018-04743-2

Nature Communications (Jun 2018)

Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Konstantin Stoletov,
Lian Willetts,
Robert J. Paproski,
David J. Bond,
Srijan Raha,
Juan Jovel,
Benjamin Adam,
Amy E. Robertson,
Francis Wong,
Emma Woolner,
Deborah L. Sosnowski,
Tarek A. Bismar,
Gane Ka-Shu Wong,
Andries Zijlstra,
John D. Lewis

Affiliations

Konstantin Stoletov: Department of Oncology, University of Alberta
Lian Willetts: Department of Oncology, University of Alberta
Robert J. Paproski: Department of Oncology, University of Alberta
David J. Bond: Department of Oncology, University of Alberta
Srijan Raha: Department of Oncology, University of Alberta
Juan Jovel: Department of Biological Sciences, University of Alberta
Benjamin Adam: Department of Laboratory Medicine and Pathology, University of Alberta
Amy E. Robertson: Department of Oncology, University of Alberta
Francis Wong: Department of Oncology, University of Alberta
Emma Woolner: Department of Oncology, University of Alberta
Deborah L. Sosnowski: Department of Oncology, University of Alberta
Tarek A. Bismar: Departments of Pathology and Laboratory Medicine, Oncology, Biochemistry and Molecular Biology, University of Calgary Cumming School of Medicine and Calgary Laboratory Services
Gane Ka-Shu Wong: Department of Biological Sciences, University of Alberta
Andries Zijlstra: Department of Pathology, Microbiology and Immunology, Vanderbilt University
John D. Lewis: Department of Oncology, University of Alberta

DOI: https://doi.org/10.1038/s41467-018-04743-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Tumour metastasis is dependent on tumour cell motility. Here, the authors investigate genes required for tumour cell motility by establishing a quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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