Frontiers in Oncology (Mar 2022)
B7H6 Serves as a Negative Prognostic Marker and an Immune Modulator in Human Pancreatic Cancer
- Zheng Zhu,
- Zheng Zhu,
- Zheng Zhu,
- Zheng Zhu,
- Zheng Zhu,
- Kun-Yu Teng,
- Jian Zhou,
- Yunyun Xu,
- Lifeng Zhang,
- Hua Zhao,
- Xueguang Zhang,
- Xueguang Zhang,
- Xueguang Zhang,
- Lei Tian,
- Zhiyao Li,
- Ting Lu,
- Shoubao Ma,
- Zhenlong Li,
- Zhenyu Dai,
- Jing Wang,
- Xingyu Chen,
- Xing Wu,
- Yihan Pan,
- Weiqiang Shi,
- Zhiqun You,
- Hanyu Chen,
- Vincent Chung,
- Jianhua Yu,
- Songbing He,
- Xin Zhao,
- Lei Cao,
- Lei Cao,
- Lei Cao,
- Dechun Li
Affiliations
- Zheng Zhu
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Zheng Zhu
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Zheng Zhu
- Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Zheng Zhu
- Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China
- Zheng Zhu
- Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Kun-Yu Teng
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Jian Zhou
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Yunyun Xu
- Pediatric Clinical Research Institute, Children’s Hospital Affiliated to Soochow University, Suzhou, China
- Lifeng Zhang
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Hua Zhao
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Xueguang Zhang
- Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Xueguang Zhang
- Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China
- Xueguang Zhang
- Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Lei Tian
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Zhiyao Li
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Ting Lu
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Shoubao Ma
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Zhenlong Li
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Zhenyu Dai
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Jing Wang
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Xingyu Chen
- Department of General Surgery, Taizhou Fourth People’s Hospital, Taizhou, China
- Xing Wu
- Department of General Surgery, The First People’s Hospital of Huzhou, Huzhou, China
- Yihan Pan
- College of Liberal Arts, University of Minnesota Twin Cities, Minneapolis, MN, United States
- Weiqiang Shi
- 0Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Zhiqun You
- 0Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Hanyu Chen
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Vincent Chung
- 1Department of Medical Oncology, City of Hope National Medical Center, Los Angeles, CA, United States
- Jianhua Yu
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA, United States
- Songbing He
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Xin Zhao
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Lei Cao
- Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Lei Cao
- Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China
- Lei Cao
- Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Dechun Li
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- DOI
- https://doi.org/10.3389/fonc.2022.814312
- Journal volume & issue
-
Vol. 12
Abstract
Pancreatic cancer (PC), the third leading cause of cancer-related death in the U.S., is frequently found too late to be cured by traditional chemotherapy. Expression of B7 homolog 6 (B7H6), a member of the B7 family of immunoreceptors, has been found in PC and several other cancers. B7H6 is a ligand for cytotoxicity triggering receptor 3 (NKp30), which is expressed on NK cells. Here, we demonstrate that B7H6 can be detected in PC tissues but not normal organs. Its expression in patients associated significantly with tumor differentiation grade and lymphatic metastasis. The soluble form of B7H6 was detected in the PC patients’ sera, and its concentration associated with tumor differentiation grade and tumor, node, metastasis (TNM) stages. Also, higher levels of B7H6 in PC patients’ malignant tissues or serum correlated with shorter overall survival. In vitro, downregulation of B7H6 by CRISPR/Cas9 or siRNA technology had no significant impact on the viability or mobility of PC cells. Instead, knocking out B7H6 sensitized PC cells to NK-mediated cytotoxicity and cytokine production. These results indicate that B7H6 not only serves as a negative prognostic marker but also acts as an immune modulator in PC.
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