RETROSPECTIVE OF DISSOLUTION TEST OF SOLID DOSAGE FORMS (REVIEW)

Abstract

The article describes the main historical stages in the development of the science of drug dissolution and the dissolution profile test from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the introduction of biowaiver based on the BCS.

Keywords

• dissolution profile test
• equivalence
• generic drugs