NONSTEROID ANTI-INFLAMMATORY DRUGS FOR THE TREATEMENT OF OSTEOARTHROSIS: COMPARATIVE EFFICACY AND TOLERABILITY OF NIMESULIDE

Abstract

Nonsteroid anti-inflammatory drugs are the fast-acting medications used widely to treat pain and inflammation for osteoarthritis. The pharmacological activity of most of them is characterized by the chondronegative action on osteoarthrosis cartilage, which manifests itself as inhibition of the chondrocyte metabolic activity and intensification of its apoptosis, which reduces the synthesis of proteoglycans, the main intercellular substance of the hyaline cartilage and thus its degeneration rates. In contrast, nimesulides show a chondronegative action. The article presents the results of a comparative randomized study evaluating the efficacy and tolerability of two Nimesulide generics, Nimesan and Nise. Nimesan was not only inferior to Nise by its characteristics, but also proved to be more efficient by the overall WOMAC index, positive dynamics of the functional capacity of the affected joints and the ESR index. Both drugs showed comparable tolerability and safety results.

Keywords

• osteoarthrosis
• nimesulide
• nimesan
• nise