Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis
Yuce Peng,
Mingyu Guo,
Minghao Luo,
Dingyi Lv,
Ke Liao,
Suxin Luo,
Bingyu Zhang
Affiliations
Yuce Peng
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China
Mingyu Guo
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China
Minghao Luo
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China
Dingyi Lv
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China
Ke Liao
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China
Suxin Luo
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Cardiovascular Disease Laboratory of Chongqing Medical University, Chongqing, 400016, China; Corresponding author. Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Bingyu Zhang
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Cardiology, Wuhu Hospital of East China Normal University, Wuhu, China; Corresponding author. Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Dapagliflozin (DAPA) has been demonstrated to reduce cardiovascular mortality and heart failure hospitalization rates in diabetic patients. However, the mechanism underlying its cardio-protective effect in non-diabetic patients remains unclear. Our study aimed to explore the cardio-protective impact of DAPA on myocardial infarction in non-diabetic mice. We induced myocardial infarction in C57BL/6 mice by ligating the descending branch of the left coronary artery. After surgery, the animals were randomly treated with either saline or DAPA. We employed echocardiography, Western blot analysis, and tissue staining to assess post-infarction myocardial injury. Additionally, we investigated the mechanism of action through cell experiments. Compared to the myocardial infarction group, DAPA treatment significantly attenuated ventricular remodeling and improved cardiac function. By mitigating myocardial oxidative stress and apoptosis, DAPA may activate the AMPKα signaling pathway, thereby exerting a protective effect. These findings suggest that DAPA could serve as a novel therapeutic approach for patients with cardiac infarction.
