Nature Communications (Jul 2018)
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
- Wei Xiang,
- Rongchen Shi,
- Xia Kang,
- Xuan Zhang,
- Peng Chen,
- Lili Zhang,
- Along Hou,
- Rui Wang,
- Yuanyin Zhao,
- Kun Zhao,
- Yingzhe Liu,
- Yue Ma,
- Huan Luo,
- Shenglan Shang,
- Jinyu Zhang,
- Fengtian He,
- Songtao Yu,
- Lixia Gan,
- Chunmeng Shi,
- Yongsheng Li,
- Wei Yang,
- Houjie Liang,
- Hongming Miao
Affiliations
- Wei Xiang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Rongchen Shi
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Xia Kang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Xuan Zhang
- Department of Oncology, Southwest Hospital, Third Military Medical University
- Peng Chen
- Department of General Surgery, PLA 324 Hospital
- Lili Zhang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Along Hou
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Rui Wang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Yuanyin Zhao
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Kun Zhao
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Yingzhe Liu
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Yue Ma
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Huan Luo
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Shenglan Shang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Jinyu Zhang
- National Engineering Research Center of Immunological Products, Third Military Medical University
- Fengtian He
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Songtao Yu
- Department of Oncology, Southwest Hospital, Third Military Medical University
- Lixia Gan
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Chunmeng Shi
- Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Yongsheng Li
- Clinical Medicine Research Center & Institute of Cancer, Xinqiao Hospital, Third Military Medical University
- Wei Yang
- Department of Pathology, School of Basic Medical Sciences & Nanfang Hospital, Southern Medical University
- Houjie Liang
- Department of Oncology, Southwest Hospital, Third Military Medical University
- Hongming Miao
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- DOI
- https://doi.org/10.1038/s41467-018-04999-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.
