Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation

Abstract

More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We report a patient with MS who developed signs typical for PD and was found to be heterozygous mutation carrier in the gene for glucocerebrosidase (GBA1), a well-known risk factor for PD.

Keywords

• Multiple sclerosis
• Parkinson's disease
• Glucocerebrosidase gene mutation