Nature Communications (Nov 2020)
Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
- Dongsheng Jiang,
- Simon Christ,
- Donovan Correa-Gallegos,
- Pushkar Ramesh,
- Shruthi Kalgudde Gopal,
- Juliane Wannemacher,
- Christoph H. Mayr,
- Valerio Lupperger,
- Qing Yu,
- Haifeng Ye,
- Martin Mück-Häusl,
- Vijayanand Rajendran,
- Li Wan,
- Juan Liu,
- Ursula Mirastschijski,
- Thomas Volz,
- Carsten Marr,
- Herbert B. Schiller,
- Yuval Rinkevich
Affiliations
- Dongsheng Jiang
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Simon Christ
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Donovan Correa-Gallegos
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Pushkar Ramesh
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Shruthi Kalgudde Gopal
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Juliane Wannemacher
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Christoph H. Mayr
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Systems Medicine of Chronic Lung Disease
- Valerio Lupperger
- Helmholtz Zentrum München, Institute of Computational Biology
- Qing Yu
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Haifeng Ye
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Martin Mück-Häusl
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Vijayanand Rajendran
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Li Wan
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Juan Liu
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- Ursula Mirastschijski
- Mira-Beau gender esthetics
- Thomas Volz
- Department of Dermatology and Allergology, Technical University of Munich, School of Medicine, Klinikum rechts der Isar
- Carsten Marr
- Helmholtz Zentrum München, Institute of Computational Biology
- Herbert B. Schiller
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Systems Medicine of Chronic Lung Disease
- Yuval Rinkevich
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Group Regenerative Biology and Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19425-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.
