mBio (Oct 2021)

Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: further Insights into Their Cooperative Action

  • Jingqi Chen,
  • Oscar P. Kuipers

DOI
https://doi.org/10.1128/mBio.02585-21
Journal volume & issue
Vol. 12, no. 5

Abstract

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Lantibiotics are ribosomally synthesized and posttranslationally modified peptide antibiotics. Although the membrane-associated lantibiotic biosynthesis machinery has long been proposed to exist, the isolation of such a complex has not been reported yet, which limits the elucidation of the processive mechanism of lantibiotic biosynthesis.