Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches

Abstract

Abstract During the last epidemic season of bronchiolitis (S2, years 2016–2017) we performed a single Centre analysis in inborn infant of 30+ 0–32+ 6 gestational age and age 30 weeks gestational age, we decided to repeat our observation during the last epidemic season (S3, years 2017–2018), in order to compare ours infants of 30+ 0–32+ 6 gestational age with preterm of the same gestational age born in our unit in the previous seasons (S1 and S2), to evaluate the clinical impact of the different prophylaxis approaches. The new observation confirmed the clinical efficacy of PLV in this delicate group of newborns in preventing almost completely new episodes of bronchiolitis. Of the 6 newborns who developed bronchiolitis, 4 had received only a single dose of PLV, providing suboptimal protection, before the onset of bronchiolitis; furthermore 3 developed a mild form allowing to be treated at home.

Keywords

• Bronchiolitis
• Prophylaxis
• Preterm
• Palivizumab