Nature Communications (Jan 2016)
A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
- Lei Yuan,
- Gary C. Chan,
- David Beeler,
- Lauren Janes,
- Katherine C. Spokes,
- Harita Dharaneeswaran,
- Anahita Mojiri,
- William J. Adams,
- Tracey Sciuto,
- Guillermo Garcia-Cardeña,
- Grietje Molema,
- Peter M. Kang,
- Nadia Jahroudi,
- Philip A. Marsden,
- Ann Dvorak,
- Erzsébet Ravasz Regan,
- William C. Aird
Affiliations
- Lei Yuan
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Gary C. Chan
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- David Beeler
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Lauren Janes
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Katherine C. Spokes
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Harita Dharaneeswaran
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Anahita Mojiri
- Department of Medicine, University of Alberta
- William J. Adams
- Department of Pathology, Beth Israel Deaconess Medical Center
- Tracey Sciuto
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Guillermo Garcia-Cardeña
- Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women's Hospital
- Grietje Molema
- Department of Pathology and Medical Biology, Medical Biology Section, University Medical Center Groningen, University of Groningen
- Peter M. Kang
- Department of Medicine, Beth Israel Deaconess Medical Center
- Nadia Jahroudi
- Department of Medicine, University of Alberta
- Philip A. Marsden
- Department of Medicine, University of Toronto
- Ann Dvorak
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Erzsébet Ravasz Regan
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- William C. Aird
- Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- DOI
- https://doi.org/10.1038/ncomms10160
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis.
