?-Trimethylsilylmethylamine Radical Cation in the Synthesis of Cyclic Amines and Beyond

Abstract

The evolution of chemistry associated with the photoinduced electron transfer (PET)-generated ?-trimethylsilylmethylamine radical cation cyclization to a tethered olefin to synthesize cyclic amine structural frame works is presented in chronological order. The importance of this interesting chemistry is demonstrated by the synthesis of several novel glycosidase inhibitors.

Keywords

• α-amine radical
• Glycosidase inhibitors
• 1-n-iminosugars
• Photoinduced electron transfer (pet)
• α-trimethylsilyl methylamine radical cation