Hemophagocytic lymphohistiocytosis and Pelger-Huët anomaly associated with colchicine intoxication

Abstract

Colchicine is frequently used in the treatment of familial Mediterranean fever (FMF). First symptoms of colchicine intoxication are gastrointestinal disturbances, such as abdominal cramps, diarrhea, pancytopenia and so on. Herein, we report a female FMF patient with pancytopenia and hemophagocytic lymphohitiocytosis (HLH), following colchicine intoxication for committing suicide. To our knowledge, this is the first reported case of a patient with HLH associated with colchicine intoxication.

Keywords

• colchicine intoxication, hemophagocytic lymphohitiocytosis, Pelger-Huët anomaly