Guoji laonian yixue zazhi (Mar 2024)
Correlation between Multiple Inflammatory Markers and Short-to Medium-termPrognosis after Endovascular Treatment for Acute Ischemic Stroke Patients
Abstract
Objective To investigate the predictive role of multiple inflammatory markers in the short- to medium-term prognosis of acute ischemic stroke patients after endovascular treatment. Methods 376 acute ischemic stroke patients treated with endovascular treatment in the Department of Neurology of the First Hospital of Harbin Medical University from January 2020 to December 2022 were retrospectively included.According to the modified Rankin scale(mRS) score at 90 d postoperatively, they were divided into 184 cases in the poor prognosis group(mRS≤2 scores) and 192 cases in the good prognosis group(mRS>2 scores).The clinical data of all patients was collected through the electronic medical record system, the risk factors for poor prognosis in elderly acute ischemic stroke patients were screened by multivariate logistic regression, and the ROC curve was used to assess the clinical value of each preoperative inflammatory index in predicting poor prognosis in elderly acute ischemic stroke patients. Results Univariate analysis showed that compared with the good prognosis group, the age>75 years, the proportion of diabetes mellitus, and the erythrocyte pressure volume, neutrophil to lymphocyte ratio(NLR), systemic immune-inflammation index(SII), fibrinogen to albumin ratio(FAR), and CRP were elevated, and the proportion of≥2b grade of modified thrombolysis in cerebral infarction(mTICI) grade was reduced at the postoperative period in the poor prognosis group(P75 years, NLR, SII, FAR were independent risk factors for poor prognosis in the near- to mid-term in elderly acute ischemic stroke patients(P<0.05), and mTICI grade≥2b was a protective factor(P<0.05).The ROC curves showed that SII predicted poor prognosis in elderly acute ischemic stroke patients with the highest AUC, followed by the NLR, and FAR had the lowest AUC on the ROC curve. Conclusion Preoperative NLR, SII, and FAR are all risk factors for and predictive of poor prognosis in the near to midterm period after endovascular treatment in elderly patients with acute ischemic stroke, with SII having the highest predictive value.
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