Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

Carlos Cinelli; Nathan LaPierre; Brian L. Hill; Sriram Sankararaman; Eleazar Eskin

doi:10.1038/s41467-022-28553-9

Nature Communications (Mar 2022)

Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

Carlos Cinelli,
Nathan LaPierre,
Brian L. Hill,
Sriram Sankararaman,
Eleazar Eskin

Affiliations

Carlos Cinelli: Department of Statistics, University of Washington
Nathan LaPierre: Department of Computer Science, University of California
Brian L. Hill: Department of Computer Science, University of California
Sriram Sankararaman: Department of Computer Science, University of California
Eleazar Eskin: Department of Computer Science, University of California

DOI: https://doi.org/10.1038/s41467-022-28553-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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The validity of Mendelian Randomization (MR) studies may be affected by population stratification, batch effects, and horizontal pleiotropy. Here, the authors develop MR-SENSEMAKR, allowing quantification of the robustness of MR findings.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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