T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Ya-nan Wang; Ya-nan Wang; Ya-nan Wang; Shiyue Liu; Shiyue Liu; Shiyue Liu; Tingting Jia; Tingting Jia; Tingting Jia; Yao Feng; Yao Feng; Yao Feng; Xin Xu; Xin Xu; Xin Xu; Dongjiao Zhang; Dongjiao Zhang; Dongjiao Zhang

doi:10.3389/fcell.2021.682947

Frontiers in Cell and Developmental Biology (Jun 2021)

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Ya-nan Wang,
Ya-nan Wang,
Ya-nan Wang,
Shiyue Liu,
Shiyue Liu,
Shiyue Liu,
Tingting Jia,
Tingting Jia,
Tingting Jia,
Yao Feng,
Yao Feng,
Yao Feng,
Xin Xu,
Xin Xu,
Xin Xu,
Dongjiao Zhang,
Dongjiao Zhang,
Dongjiao Zhang

Affiliations

Ya-nan Wang: Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Ya-nan Wang: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Ya-nan Wang: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China
Shiyue Liu: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Shiyue Liu: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China
Shiyue Liu: Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Tingting Jia: Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Tingting Jia: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Tingting Jia: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China
Yao Feng: Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Yao Feng: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Yao Feng: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China
Xin Xu: Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Xin Xu: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Xin Xu: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China
Dongjiao Zhang: Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China
Dongjiao Zhang: Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China
Dongjiao Zhang: Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China

DOI: https://doi.org/10.3389/fcell.2021.682947
Journal volume & issue: Vol. 9

Abstract

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T cell protein tyrosine phosphatase (TCPTP), a vital regulator in glucose metabolism, inflammatory responses, and tumor processes, is increasingly considered a promising target for disease treatments and illness control. This review discusses the structure, substrates and main biological functions of TCPTP, as well as its regulatory effect in glucose metabolism, as an attempt to be referenced for formulating treatment strategies of metabolic disorders. Given the complicated regulation functions in different tissues and organs of TCPTP, the development of drugs inhibiting TCPTP with a higher specificity and a better biocompatibility is recognized as a promising therapeutic strategy for diabetes or obesity. Besides, treatments targeting TCPTP in a specific tissue or organ are suggested to be considerably promising.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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