A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius

Kun Wang; David Sybers; Hassan Ramadan Maklad; Liesbeth Lemmens; Charlotte Lewyllie; Xiaoxiao Zhou; Frank Schult; Christopher Bräsen; Bettina Siebers; Karin Valegård; Ann-Christin Lindås; Eveline Peeters

doi:10.1038/s41467-019-09479-1

Nature Communications (Apr 2019)

A TetR-family transcription factor regulates fatty acid metabolism in the archaeal model organism Sulfolobus acidocaldarius

Kun Wang,
David Sybers,
Hassan Ramadan Maklad,
Liesbeth Lemmens,
Charlotte Lewyllie,
Xiaoxiao Zhou,
Frank Schult,
Christopher Bräsen,
Bettina Siebers,
Karin Valegård,
Ann-Christin Lindås,
Eveline Peeters

Affiliations

Kun Wang: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
David Sybers: Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel
Hassan Ramadan Maklad: Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel
Liesbeth Lemmens: Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel
Charlotte Lewyllie: Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel
Xiaoxiao Zhou: Molekulare Enzymtechnologie und Biochemie, Biofilm Centre, ZWU, Fakultät für Chemie, Universität Duisburg-Essen
Frank Schult: Molekulare Enzymtechnologie und Biochemie, Biofilm Centre, ZWU, Fakultät für Chemie, Universität Duisburg-Essen
Christopher Bräsen: Molekulare Enzymtechnologie und Biochemie, Biofilm Centre, ZWU, Fakultät für Chemie, Universität Duisburg-Essen
Bettina Siebers: Molekulare Enzymtechnologie und Biochemie, Biofilm Centre, ZWU, Fakultät für Chemie, Universität Duisburg-Essen
Karin Valegård: Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University
Ann-Christin Lindås: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Eveline Peeters: Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel

DOI: https://doi.org/10.1038/s41467-019-09479-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Certain archaea appear to metabolize fatty acids, but the regulation of these pathways is unclear. Here, Wang et al. provide genetic, functional and structural evidence supporting that a TetR-family transcriptional regulator is involved in regulation of fatty acid metabolism in Sulfolobus acidocaldarius.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal