Clinical Ophthalmology (Jun 2024)

Five-Year Incidence of Nd:YAG Capsulotomy After Cataract Surgery with Different Single-Piece Monofocal Intraocular Lenses: A Follow-Up Study of 3955 Eyes

  • Belda JI,
  • Placeres J,
  • Elvira JC,
  • Puig X,
  • Pérez-Vives C,
  • Zou M,
  • Yu J,
  • Sun S,
  • O’Boyle D

Journal volume & issue
Vol. Volume 18
pp. 1599 – 1605

Abstract

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José I Belda,1,2 Javier Placeres,1,2 Juan C Elvira,3 Xavier Puig,4 Caridad Pérez-Vives,5 Ming Zou,6 Jing Yu,6 Shaohui Sun,6 Derek O’Boyle7 1Department of Ophthalmology, Hospital Universitario de Torrevieja, Alicante, Spain; 2Visionker Eye Clinic, Alicante, Spain; 3Department of Ophthalmology, Hospital Universitario del Vinalopó, Alicante, Spain; 4Alcon Healthcare SA, Barcelona, Spain; 5Alcon Management SA, Cointrin, Switzerland; 6IQVIA Real World Solutions, Basel, Switzerland; 7Alcon Laboratories Ireland Ltd, Cork, IrelandCorrespondence: Derek O’Boyle, Alcon Laboratories Ireland Ltd., Cork, Ireland, Tel +353879080235, Email [email protected]: To estimate the incidence of neodymium-doped yttrium aluminum garnet laser (Nd:YAG) capsulotomy up to five years after cataract surgery with different single-piece acrylic monofocal IOLs in a Spanish cohort.Patients and Methods: Data were extracted from electronic medical records. Eligible participants were aged ≥ 65, had cataract surgery with one of five different acrylic monofocal IOLs (Alcon AcrySof, AJL LLASY60, Medicontur Bi-flex, IOL Tech Stabibag and Zeiss Asphina), and more than six months baseline data. Participants were followed up to five years from surgery and up to six months from Nd:YAG. The incidence of Nd:YAG was compared between the IOLs and multivariate analyses were conducted to identify predictors of Nd:YAG incidence at five-years after cataract surgery.Results: The initial cohort included 9545 patients with 14,519 eyes (53% female, average age 75 years). Of those, 3955 eyes were available for analysis five years after cataract surgery. Throughout the five years post-surgery, Nd:YAG incidence was consistently lower with Alcon Acrysof IOLs than the other IOLs. At five years the Nd:YAG incidence rate for Alcon Acrysof was 8.8%. In comparison, the incidence was 47.4% for AJL LLASY60 (OR = 9.54, 95% CI [6.57, 13.84]), 44.3% for Zeiss Asphina (OR = 8.35, 95% CI [5.85, 11.94]) and 44.0% for IOL Tech Stabibag (OR = 8.02, 95% CI [4.60, 13.84]).Conclusion: Alcon AcrySof IOLs have a consistently lower risk of Nd:YAG incidence over a long follow-up period after cataract surgery, highlighting the importance of IOL choice for patients’ long-term outcomes.Keywords: Nd:YAG, long-term outcome, monofocal IOLs, real-world evidence

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