Nature Communications (Oct 2020)
Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy
- D. J. Woodcock,
- E. Riabchenko,
- S. Taavitsainen,
- M. Kankainen,
- G. Gundem,
- D. S. Brewer,
- P. Ellonen,
- M. Lepistö,
- Y. A. Golubeva,
- A. C. Warner,
- T. Tolonen,
- J. Jasu,
- W. B. Isaacs,
- M. R. Emmert-Buck,
- M. Nykter,
- T. Visakorpi,
- G. S. Bova,
- D. C. Wedge
Affiliations
- D. J. Woodcock
- Big Data Institute, University of Oxford
- E. Riabchenko
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- S. Taavitsainen
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- M. Kankainen
- Medical and Clinical Genetics and Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital
- G. Gundem
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- D. S. Brewer
- Norwich Medical School, University of East Anglia
- P. Ellonen
- Institute for Molecular Medicine Finland, University of Helsinki
- M. Lepistö
- Institute for Molecular Medicine Finland, University of Helsinki
- Y. A. Golubeva
- Cancer Genomic Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, NCI, FNLCR, Leidos Biomedical Research, Inc
- A. C. Warner
- Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research
- T. Tolonen
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- J. Jasu
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- W. B. Isaacs
- Brady Urological Institute, Johns Hopkins University School of Medicine
- M. R. Emmert-Buck
- Laboratory of Pathology, National Cancer Institute, National Institutes of Health
- M. Nykter
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- T. Visakorpi
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- G. S. Bova
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center
- D. C. Wedge
- Big Data Institute, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-020-18843-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolution both within the prostate and during metastasis in ten men.
