Nature Communications (Oct 2018)
Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
Abstract
Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumping.