Biocompatibility of Ceramic Materials in Ca<sub>2</sub>P<sub>2</sub>O<sub>7–</sub>Ca(PO<sub>3</sub>)<sub>2</sub> System Obtained via Heat Treatment of Cement-Salt Stone
Otabek Toshev,
Tatiana Safronova,
Maksim Kaimonov,
Tatiana Shatalova,
Elena Klimashina,
Yulia Lukina,
Konstantin Malyutin,
Sergey Sivkov
Affiliations
Otabek Toshev
Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia
Tatiana Safronova
Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia
Maksim Kaimonov
Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia
Tatiana Shatalova
Department of Materials Science, Lomonosov Moscow State University, Building, 73, Leninskie Gory, 1, 119991 Moscow, Russia
Elena Klimashina
Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, Russia
Yulia Lukina
National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Priorova, 10, 127299 Moscow, Russia
Konstantin Malyutin
Skolkovo Institute of Science and Technology, Bolshoy Boulevard, 30, 121205 Moscow, Russia
Sergey Sivkov
Faculty of Technology of Inorganic Substances and High-Temperature Materials, Mendeleev University of Chemical Technology of Russia, Miusskaya pl., 9, 125047 Moscow, Russia
Biocompatibility of ceramic materials in Ca2P2O7-Ca(PO3)2 system was investigated using different methods, including in vitro and in vivo tests. Ceramic materials in the Ca2P2O7-Ca(PO3)2 system were obtained by annealing cement-salt stone based on powder mixtures of calcium citrate tet-rahydrate Ca3(C6H5O7)2·4H2O and monocalcium phosphate monohydrate (MCPM) Ca(H2PO4)2·H2O. The phase composition of cement-salt stone included brushite, monetite as a result of chemical reaction of starting components after adding of water. The presence of citric acid as by-product of chemical reaction, leads to increase the setting time of the cement-salt stone. Highly concentrated aqueous suspensions based on calcium citrate and MCPM powders providing content of calcium polyphosphate Ca(PO3)2 up to 20 wt % in ceramics were used for designing bioresorbable materials. The presence of an excess of monocalcium phosphate monohydrate makes it possible to reduce the annealing temperature of ceramics, which is associated with the formation of a lower melting phase of Ca(PO3)2. In vivo tests shown that obtained ceramic materials can be recommended for regenerative treatments for bone defects.
