Nature Communications (Jan 2022)

Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

  • Jianan Zhang,
  • Morgan E. Walker,
  • Katherine Z. Sanidad,
  • Hongna Zhang,
  • Yanshan Liang,
  • Ermin Zhao,
  • Katherine Chacon-Vargas,
  • Vladimir Yeliseyev,
  • Julie Parsonnet,
  • Thomas D. Haggerty,
  • Guangqiang Wang,
  • Joshua B. Simpson,
  • Parth B. Jariwala,
  • Violet V. Beaty,
  • Jun Yang,
  • Haixia Yang,
  • Anand Panigrahy,
  • Lisa M. Minter,
  • Daeyoung Kim,
  • John G. Gibbons,
  • LinShu Liu,
  • Zhengze Li,
  • Hang Xiao,
  • Valentina Borlandelli,
  • Hermen S. Overkleeft,
  • Erica W. Cloer,
  • Michael B. Major,
  • Dennis Goldfarb,
  • Zongwei Cai,
  • Matthew R. Redinbo,
  • Guodong Zhang

DOI
https://doi.org/10.1038/s41467-021-27762-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Triclosan (TCS), an antimicrobial agent commonly found in consumer products, has been reported to exacerbates colitis in animal models. Here, using in vitro and in vivo approaches, the authors show that gut bacterial enzymes can drive the metabolic activation and gut toxicity of TCS, highlighting an important role of intestinal microbial factors in the complex etiology of colitis.