Nature Communications (Jan 2022)
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
- Jianan Zhang,
- Morgan E. Walker,
- Katherine Z. Sanidad,
- Hongna Zhang,
- Yanshan Liang,
- Ermin Zhao,
- Katherine Chacon-Vargas,
- Vladimir Yeliseyev,
- Julie Parsonnet,
- Thomas D. Haggerty,
- Guangqiang Wang,
- Joshua B. Simpson,
- Parth B. Jariwala,
- Violet V. Beaty,
- Jun Yang,
- Haixia Yang,
- Anand Panigrahy,
- Lisa M. Minter,
- Daeyoung Kim,
- John G. Gibbons,
- LinShu Liu,
- Zhengze Li,
- Hang Xiao,
- Valentina Borlandelli,
- Hermen S. Overkleeft,
- Erica W. Cloer,
- Michael B. Major,
- Dennis Goldfarb,
- Zongwei Cai,
- Matthew R. Redinbo,
- Guodong Zhang
Affiliations
- Jianan Zhang
- Department of Food Science, University of Massachusetts
- Morgan E. Walker
- Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill
- Katherine Z. Sanidad
- Department of Food Science, University of Massachusetts
- Hongna Zhang
- State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University
- Yanshan Liang
- State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University
- Ermin Zhao
- Department of Food Science, University of Massachusetts
- Katherine Chacon-Vargas
- Department of Food Science, University of Massachusetts
- Vladimir Yeliseyev
- Massachusetts Host-Microbiota Center, Department of Pathology, Brigham and Women’s Hospital
- Julie Parsonnet
- Department of Medicine and Department of Health Research and Policy, Stanford University
- Thomas D. Haggerty
- Department of Medicine and Department of Health Research and Policy, Stanford University
- Guangqiang Wang
- Department of Food Science, University of Massachusetts
- Joshua B. Simpson
- Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill
- Parth B. Jariwala
- Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill
- Violet V. Beaty
- Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill
- Jun Yang
- Department of Entomology and Nematology, University of California
- Haixia Yang
- Department of Food Science, University of Massachusetts
- Anand Panigrahy
- Department of Food Science, University of Massachusetts
- Lisa M. Minter
- Department of Veterinary & Animal Sciences, University of Massachusetts
- Daeyoung Kim
- Department of Mathematics and Statistics, University of Massachusetts
- John G. Gibbons
- Department of Food Science, University of Massachusetts
- LinShu Liu
- Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture
- Zhengze Li
- Department of Food Science, University of Massachusetts
- Hang Xiao
- Department of Food Science, University of Massachusetts
- Valentina Borlandelli
- Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University
- Hermen S. Overkleeft
- Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University
- Erica W. Cloer
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Michael B. Major
- Department of Cell Biology and Physiology, and Department of Otolaryngology, Washington University
- Dennis Goldfarb
- Department of Cell Biology and Physiology, Institute for Informatics, Washington University
- Zongwei Cai
- State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University
- Matthew R. Redinbo
- Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill
- Guodong Zhang
- Department of Food Science, University of Massachusetts
- DOI
- https://doi.org/10.1038/s41467-021-27762-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Triclosan (TCS), an antimicrobial agent commonly found in consumer products, has been reported to exacerbates colitis in animal models. Here, using in vitro and in vivo approaches, the authors show that gut bacterial enzymes can drive the metabolic activation and gut toxicity of TCS, highlighting an important role of intestinal microbial factors in the complex etiology of colitis.
