Nature Communications (May 2022)
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
- Odeta Meçe,
- Diede Houbaert,
- Maria-Livia Sassano,
- Tania Durré,
- Hannelore Maes,
- Marco Schaaf,
- Sanket More,
- Maarten Ganne,
- Melissa García-Caballero,
- Mila Borri,
- Jelle Verhoeven,
- Madhur Agrawal,
- Kathryn Jacobs,
- Gabriele Bergers,
- Silvia Blacher,
- Bart Ghesquière,
- Mieke Dewerchin,
- Johan V. Swinnen,
- Stefan Vinckier,
- María S. Soengas,
- Peter Carmeliet,
- Agnès Noël,
- Patrizia Agostinis
Affiliations
- Odeta Meçe
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Diede Houbaert
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Maria-Livia Sassano
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Tania Durré
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Hannelore Maes
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Marco Schaaf
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Sanket More
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Maarten Ganne
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Melissa García-Caballero
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB
- Mila Borri
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB
- Jelle Verhoeven
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Madhur Agrawal
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Kathryn Jacobs
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- Gabriele Bergers
- Laboratory for Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, KU Leuven
- Silvia Blacher
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Bart Ghesquière
- Metabolomics Expertise Center, Department of Oncology, KU Leuven
- Mieke Dewerchin
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB
- Johan V. Swinnen
- Laboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven
- Stefan Vinckier
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB
- María S. Soengas
- Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
- Peter Carmeliet
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB
- Agnès Noël
- Laboratory of Tumor and Development Biology, GIGA (GIGA-Cancer), Liege University
- Patrizia Agostinis
- Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine, KU Leuven
- DOI
- https://doi.org/10.1038/s41467-022-30490-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.
