An Intestinal Microbiome Intervention Affects Biochemical Disease Activity in Patients with Antiphospholipid Syndrome

Valérie L. B. I. Jansen; Dagmar J. M. van Mourik; Mark Davids; Kika van Bergen en Henegouwen; Tessa Noordermeer; Johannes H. M. Levels; Maarten Limper; Michiel Coppens; Max Nieuwdorp; Rolf T. Urbanus; Saskia Middeldorp; Thijs E. van Mens

doi:10.1055/s-0044-1788653

TH Open (Jul 2024)

An Intestinal Microbiome Intervention Affects Biochemical Disease Activity in Patients with Antiphospholipid Syndrome

Valérie L. B. I. Jansen,
Dagmar J. M. van Mourik,
Mark Davids,
Kika van Bergen en Henegouwen,
Tessa Noordermeer,
Johannes H. M. Levels,
Maarten Limper,
Michiel Coppens,
Max Nieuwdorp,
Rolf T. Urbanus,
Saskia Middeldorp,
Thijs E. van Mens

Affiliations

Valérie L. B. I. Jansen: Department of Vascular Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands
Dagmar J. M. van Mourik: Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands
Mark Davids: Department of Experimental Vascular Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, The Netherlands
Kika van Bergen en Henegouwen: Department of Vascular Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands
Tessa Noordermeer: Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands
Johannes H. M. Levels: Department of Experimental Vascular Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, The Netherlands
Maarten Limper: Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Michiel Coppens: Department of Vascular Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands
Max Nieuwdorp: Department of Vascular Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands
Rolf T. Urbanus: Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands
Saskia Middeldorp: Department of Internal Medicine and Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands
Thijs E. van Mens: Department of Vascular Medicine, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, The Netherlands

DOI: https://doi.org/10.1055/s-0044-1788653
Journal volume & issue: Vol. 08, no. 03
pp. e308 – e316

Abstract

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Background The origin of autoantibodies in patients with antiphospholipid syndrome (APS) is unknown. The gut microbiome contributes to autoimmunity and contains peptide homologues to the main APS autoantigen, which affect disease activity in animal models. Alteration of the gut microbiota with vancomycin diminishes disease activity in mice but no data on the effect of gut microbiota alteration in APS patients are available to date.

Published in TH Open

ISSN: 2512-9465 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://doi.org/10.1055/s-00033990

About the journal

Abstract

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