Immune landscape and prognostic index for pancreatic cancer based on TCGA database and in vivo validation

Abstract

Highlights M0 macrophages accounted for more than 9.8%, indicating a poor prognosis in pancreatic cancer. M0 macrophages proportion were negatively correlated with CD8 + T cells, and immune scores. M0 macrophages promote pancreatic cancer growth in vivo. Elimination of M0 macrophages may be a promising strategy against PAAD.

Keywords

• Pancreatic cancer
• Immune landscape
• Prognosis
• M0 macrophage