Nature Communications (Jul 2021)
Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
- Babatunde Adedokun,
- Zhaohui Du,
- Guimin Gao,
- Thomas U. Ahearn,
- Kathryn L. Lunetta,
- Gary Zirpoli,
- Jonine Figueroa,
- Esther M. John,
- Leslie Bernstein,
- Wei Zheng,
- Jennifer J. Hu,
- Regina G. Ziegler,
- Sarah Nyante,
- Elisa V. Bandera,
- Sue A. Ingles,
- Michael F. Press,
- Sandra L. Deming-Halverson,
- Jorge L. Rodriguez-Gil,
- Song Yao,
- Temidayo O. Ogundiran,
- Oladosu Ojengbede,
- William Blot,
- Melissa A. Troester,
- Katherine L. Nathanson,
- Anselm Hennis,
- Barbara Nemesure,
- Stefan Ambs,
- Peter N. Fiorica,
- Lara E. Sucheston-Campbell,
- Jeannette T. Bensen,
- Lawrence H. Kushi,
- Gabriela Torres-Mejia,
- Donglei Hu,
- Laura Fejerman,
- Manjeet K. Bolla,
- Joe Dennis,
- Alison M. Dunning,
- Douglas F. Easton,
- Kyriaki Michailidou,
- Paul D. P. Pharoah,
- Qin Wang,
- Dale P. Sandler,
- Jack A. Taylor,
- Katie M. O’Brien,
- Cari M. Kitahara,
- Adeyinka G. Falusi,
- Chinedum Babalola,
- Joel Yarney,
- Baffour Awuah,
- Beatrice Addai-Wiafe,
- The GBHS Study Team,
- Stephen J. Chanock,
- Andrew F. Olshan,
- Christine B. Ambrosone,
- David V. Conti,
- Elad Ziv,
- Olufunmilayo I. Olopade,
- Montserrat Garcia-Closas,
- Julie R. Palmer,
- Christopher A. Haiman,
- Dezheng Huo
Affiliations
- Babatunde Adedokun
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago
- Zhaohui Du
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California
- Guimin Gao
- Department of Public Health Sciences, University of Chicago
- Thomas U. Ahearn
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kathryn L. Lunetta
- Department of Biostatistics, Boston University School of Public Health
- Gary Zirpoli
- Slone Epidemiology Center, Boston University
- Jonine Figueroa
- Usher Institute and CRUK Edinburgh Centre, University of Edinburgh
- Esther M. John
- Departments of Epidemiology & Population Health and of Medicine (Oncology) and Stanford Cancer Institute, Stanford University School of Medicine
- Leslie Bernstein
- Biomarkers of Early Detection and Prevention, Department of Population Sciences, Beckman Research Institute, City of Hope Comprehensive Cancer Center
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University
- Jennifer J. Hu
- Department of Public Health Sciences, University of Miami
- Regina G. Ziegler
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sarah Nyante
- Department of Radiology, University of North Carolina
- Elisa V. Bandera
- Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey
- Sue A. Ingles
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California
- Michael F. Press
- Department of Pathology, Keck School of Medicine, University of Southern California
- Sandra L. Deming-Halverson
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University
- Jorge L. Rodriguez-Gil
- Genomics, Development and Disease Section, Genetic Disease Research Branch, National Human Genome Research Institute, NIH
- Song Yao
- Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center
- Temidayo O. Ogundiran
- Department of Surgery, College of Medicine, University of Ibadan
- Oladosu Ojengbede
- Center for Population and Reproductive Health, College of Medicine, University of Ibadan
- William Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University
- Melissa A. Troester
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Katherine L. Nathanson
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania
- Anselm Hennis
- University of the West Indies
- Barbara Nemesure
- Department of Family, Population and Preventive Medicine, Stony Brook University
- Stefan Ambs
- Laboratory of Human Carcinogenesis, National Cancer Institute
- Peter N. Fiorica
- Department of Public Health Sciences, University of Chicago
- Lara E. Sucheston-Campbell
- Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University
- Jeannette T. Bensen
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Lawrence H. Kushi
- Division of Research, Kaiser Permanente Northern California
- Gabriela Torres-Mejia
- Center for Population Health Research, Instituto Nacional de Salud Publica
- Donglei Hu
- Department of Medicine, University of California San Francisco
- Laura Fejerman
- Department of Medicine, University of California San Francisco
- Manjeet K. Bolla
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Joe Dennis
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Kyriaki Michailidou
- Biostatistics Unit, The Cyprus Institute of Neurology & Genetics
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Qin Wang
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Dale P. Sandler
- Epidemiology Branch, National Institute of Environmental Health Sciences, NIH
- Jack A. Taylor
- Epidemiology Branch, National Institute of Environmental Health Sciences, NIH
- Katie M. O’Brien
- Epidemiology Branch, National Institute of Environmental Health Sciences, NIH
- Cari M. Kitahara
- Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Adeyinka G. Falusi
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Chinedum Babalola
- Department of Pharmaceutical Chemistry, University of Ibadan
- Joel Yarney
- Korle Bu Teaching Hospital
- Baffour Awuah
- Komfo Anokye Teaching Hospital
- Beatrice Addai-Wiafe
- Peace and Love Hospital
- The GBHS Study Team
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Andrew F. Olshan
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Christine B. Ambrosone
- Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center
- David V. Conti
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California
- Elad Ziv
- Department of Medicine, University of California San Francisco
- Olufunmilayo I. Olopade
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago
- Montserrat Garcia-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Julie R. Palmer
- Slone Epidemiology Center, Boston University
- Christopher A. Haiman
- Department of Preventative Medicine, Keck School of Medicine, University of Southern California
- Dezheng Huo
- Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago
- DOI
- https://doi.org/10.1038/s41467-021-24327-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with breast cancer risk among women of African ancestry.
