IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

U. Westin; E. Lundberg; K. Ohlsson

doi:10.1080/09629359891162

Mediators of Inflammation (Jan 1998)

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

U. Westin,
E. Lundberg,
K. Ohlsson

Affiliations

U. Westin: Department of Otolaryngology and Head and Neck Surgery, University Hospital of Malmö, University of Lund, Malmö SE-205 02, Sweden
E. Lundberg: Department of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, Sweden
K. Ohlsson: Department of Surgical Pathophysiology, University Hospital of Malmö, University of Lund, Malmö SE-205 02, Sweden

DOI: https://doi.org/10.1080/09629359891162
Journal volume & issue: Vol. 7, no. 3
pp. 217 – 220

Abstract

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The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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